CellDEG GmbH
enhancing photoautotrophic growth

 

patented membrane bioreactors

novel HDC photobioreactor systems for extreme
biomass concentration and highest productivity

 

HighDensityCultivation-Technology

  • membrane mediated CO2 supply

  • biomass concentration up to 30g dry weight per liter

  • productivity up to 10 g dry weight per liter & day

  • no carbon limitation, no oxygen stress, no water vapor loss

  • high quantum yield at PFD > 1000 μE

  • axenic cultivation in a closed system

  • screening systems with up to 45 replicates

Cultivation Systems

Uniform features of this reactor technology are turbulently moving cell suspensions with low layer thickness, a highly permeable basal membrane and closed (gas) compartments. We have realized laboratory-scale reactors (10, 100 and 1500 ml) as well as special reactors on demand. The cultivators are particularly suitable for parallelized cultivation of any research questions as well as preparative approaches for the production of high-density biomass.
For more information, please visit the product page

Testimonials

  • We have used the CellDEG cultivation system in several projects, e.g. precursor-feeding studies and studies on the transcription of genes involved in the biosynthesis of natural products. For all these experiments, comparability between many small-scale cultures was important, and we could make good use of the capabilities of the HDC 45.10 platform in conjunction with the Growth Control Unit.

    Prof. Timo Niedermeyer, Halle Germany

     

  • Traditional bubble columns are cumbersome and require a supply of pressurised gas, therefore, their application is, traditionally, stationary and limited to thermostatted rooms or water baths. The CellDEG cultivators offer an all-in-one solution that combines the portability of flask cultivation with the possibility of supplying CO2. They can be used with virtually all shakers and shaking incubators and offer reproducible growth conditions across different facilities and/or institutions. After testing the CellDEG cultivators we can confidently say we are satisfied with the technology.
    Dr. David A. Russo, Copenhagen Denmark

  • For our medium-to high throughput studies of cyanobacterial production strains, we rely on highly efficient and robust cultivation systems.
    Using CellDEG’s membrane-based High-Density cultivation platform, yet we are able to obtain more than five times higher biomass yields within four days than with our best-performing reactor system so far.
    This technology promises to allow for rapid screening assays as well as for viable long-term experiments with industrially relevant production rates.

    Dr. Dennis Dienst, Uppsala Sweden

  • We are using the CellDEG system for about one month in our lab now. At the beginning it was a bit difficult to get it running, but once it worked well it gave us the fastest growing cyanobacteria culture we ever had.

    Prof. Dr. Annegret Wilde, Freiburg Germany

     

     

  • I.e. Our bioreactor give 60-70 g of dry cells from 32 Liter medium and DEG gives 5 – 6.5 g of dry cells from 300 mL medium, Roughly it is 10 times more efficient.

    Mohamed Ibrahim, Berlin Germany

     

     

     

For more information, see the techonology page

Parallelizable, Replicable, Transferable, Scalable

A number of studies have shown that the parallelized HDC cultivation systems reproducibly deliver results that exceed those of classical approaches in a multiple manner. It has also already been demonstrated that this significant increase in productivity is transferable for a wide range of species and can be achieved in different volumes.
For more information, please visit the references page

Control technology and sensors

In addition to the cultivation platforms, we offer the corresponding control and regulation technology, sensors for cell density measurement (online or non-invasive samples) as well as appropriate devices for temperature control and illumination. For more information, please visit the product page.

CellDEG GmbH
Prinzenallee 78-79
D-13357 Berlin
GERMANY

 

Tel.: +49 30 2433 1959
Fax: +49 30 2433 1961
email: mail@celldeg.com
web: www.celldeg.com